TitleUse of magnesium citrate in the prophylaxis of vestibular migraine in childhood
Publication TypeJournal Article
Year of Publication2022
AuthorsMessina, Aldo, Francesco Ciodaro, Alessandro Corvaia, Simona Di Liberto, and Chiara Marino
Secondary TitleAudiologia e Foniatria
Date Published05/2022
PublisherPadova University Press
Place PublishedPadova, IT
ISSN Number2531-7008
KeywordsGABA, Glutamate, Magnesium, Magnesium citrate, Resting membrane potential, Sodium / Potassium pump, Vestibular migraine

Magnesium is involved in protein synthesis, muscle contraction, cardiac excitability, glycolysis, hormonal synthesis and in the production of at least 300 human enzymes. In this case, enzymes with an energetic function are involved and the presence of magnesium in the enzymes responsible for anaerobic glycolysis is a confirmation of this. ATP synthetase has magnesium as a cofactor. And the same is true for ATP stabilization systems, which therefore always acts as an ATPMagnesium complex. The Magnesium-ATP complex governs all the “membrane pumps” (such as the Sodium / Potassium and Calcium pumps) of our organism. Magnesium deficiency plays an important role in the pathogenesis of migraine, both in adults and in children, promoting “cortical spreading depression”. The authors studied a sample of 15 children affected by vestibular migraine who were treated with magnesium citrate, concluding that magnesium could represent a valid aid, without side effects, for the therapy of vestibular migraine even in childhood.